Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8175570 | 0.91 | CA9 (0.52) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL8174610 | 0.91 | PTGS2 (0.55) | PTGS2MAPK8PTGS1MAPK9MAPK10 | |
| SCHEMBL8176088 | 0.90 | PTGS2 (0.56) | PTGS2MAPK8PTGS1MAPK9MAPK10 | |
| SCHEMBL7777566 | 0.90 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL7777989 | 0.87 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8181641 | 0.85 | PTGS2 (0.52) | PTGS2MAPK8PTGS1 | |
| SCHEMBL8181707 | 0.85 | PTGS2 (0.51) | PTGS2MAPK8PTGS1CA12CA1 | |
| SCHEMBL7779814 | 0.84 | PTGS2 (0.63) | PTGS2PTGS1 | |
| SCHEMBL8176221 | 0.83 | CA12 (0.53) | PTGS2PTGS1MAPK9CA12CA1 | |
| SCHEMBL8630923 | 0.82 | MAPK8 (0.54) | PTGS2MAPK8PTGS1MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |