Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 4/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629948 | 0.92 | PTGS2 (0.45) | PTGS2PTGS1F10KDM1AKCNH2 | |
| SCHEMBL8634520 | 0.91 | PTGS2 (0.44) | PTGS2PTGS1F10KDM1API4KB | |
| SCHEMBL8634717 | 0.89 | PTGS2 (0.43) | PTGS2PTGS1F10KDM1API4KB | |
| SCHEMBL8630470 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1F10ABCB11ALDH1A1 | |
| SCHEMBL7778069 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8631453 | 0.85 | PTGS2 (0.47) | PTGS2PTGS1F10ABCB11ALDH1A1 | |
| SCHEMBL8631748 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1F10ABCB11ALDH1A1 | |
| SCHEMBL8634273 | 0.85 | PTGS2 (0.49) | PTGS2PTGS1F10ABCB11ALDH1A1 | |
| SCHEMBL8632244 | 0.84 | PTGS2 (0.45) | PTGS2PTGS1F10KDM1AKCNH2 | |
| SCHEMBL8629941 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1F10L3MBTL1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |