SCHEMBL8635862

SCHEMBL8635862

CC(Oc1ccc(N2CCN(c3ccncc3)CC2)cc1)C(=O)ONC=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 1/20 0.48
ITGA2B P08514 1/20 0.48
ALDH1A1 P00352 2/20 0.44
GAA P10253 1/20 0.44
ROCK2 O75116 1/20 0.41
HRH3 Q9Y5N1 4/20 0.40
MAPT P10636 2/20 0.40
USP2 O75604 1/20 0.40
ALOX15 P16050 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
LMNA P02545 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
HIF1A Q16665 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
KDM4E B2RXH2 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8633220 0.88 HRH3 (0.42) ITGB3ITGA2BALDH1A1GAAROCK2
SCHEMBL8633547 0.79 TSHR (0.42) ITGB3ITGA2BALDH1A1GAAROCK2
SCHEMBL7395120 0.76 ITGB3 (0.58) ITGB3ITGA2BALDH1A1GAAROCK2
SCHEMBL8838177 0.75 CHKA (0.42) ITGB3ITGA2BALDH1A1GAAROCK2
SCHEMBL7407502 0.74 ITGB3 (0.48) ITGB3ITGA2BALDH1A1GAAROCK2
SCHEMBL7398345 0.74 ITGB3 (0.53) ITGB3ITGA2BALDH1A1GAAROCK2
SCHEMBL7398343 0.72 ITGB3 (0.54) ITGB3ITGA2BALDH1A1GAAROCK2
Hydrochloric Acid SCHEMBL8632129 0.72 HRH3 (0.43) ITGB3ITGA2BROCK2HRH3LMNA
SCHEMBL7401786 0.71 ITGB3 (0.53) ITGB3ITGA2BALDH1A1GAAROCK2
SCHEMBL7402992 0.71 ITGB3 (0.50) ITGB3ITGA2BALDH1A1GAAROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed
US-5728701-A INHIBIT PLATELET AGGREGATION ZENECA LIMITED (GB) 1998-03-17 US disclosed