Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 13/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639531 | 0.92 | LTA4H (0.47) | LTA4HHRH1FAAHACHESCN1A | |
| SCHEMBL8640176 | 0.83 | HRH1 (0.45) | LTA4HHRH1HRH3 | |
| SCHEMBL8641258 | 0.82 | LTA4H (0.47) | LTA4HHRH1FAAHACHESCN1A | |
| SCHEMBL8637140 | 0.80 | HRH1 (0.45) | LTA4HHRH1HRH3 | |
| SCHEMBL8641249 | 0.78 | LTA4H (0.47) | LTA4HHRH1SCN3AHRH3 | |
| SCHEMBL7139209 | 0.76 | LTA4H (0.58) | LTA4H | |
| SCHEMBL8641938 | 0.75 | LTA4H (0.52) | LTA4HHRH1SCN1ASCN2ASCN3A | |
| SCHEMBL8639324 | 0.74 | LTA4H (0.54) | LTA4H | |
| SCHEMBL8641861 | 0.73 | LTA4H (0.47) | LTA4HHRH1 | |
| SCHEMBL8637399 | 0.71 | LTA4H (0.47) | LTA4HACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |