Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6520780 | 0.94 | PTGS2 (0.48) | PTGS2PIK3CAPTGS1HTR6PDPK1 | |
| SCHEMBL8640765 | 0.89 | PTGS1 (0.51) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8638826 | 0.87 | PTGS2 (0.49) | PTGS2PIK3CAPTGS1PDPK1CYP2C9 | |
| SCHEMBL6515865 | 0.85 | PDPK1 (0.45) | PTGS2PIK3CAPTGS1PDPK1CYP3A4 | |
| SCHEMBL6517839 | 0.85 | PTGS2 (0.47) | PTGS2PIK3CAPTGS1HTR6PDPK1 | |
| SCHEMBL8641438 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1PDPK1TSHRCYP3A4 | |
| SCHEMBL8641774 | 0.83 | PTGS2 (0.41) | PTGS2PTGS1PDPK1TSHRKMT2A | |
| SCHEMBL8637254 | 0.82 | PTGS2 (0.53) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8643941 | 0.82 | PTGS2 (0.42) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8641577 | 0.82 | PTGS2 (0.49) | PTGS2PTGS1PDPK1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |