Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 15/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639324 | 0.91 | LTA4H (0.54) | LTA4HNPC1RAB9ACYP2C19SMN1; SMN2 | |
| SCHEMBL8641938 | 0.82 | LTA4H (0.52) | LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8637399 | 0.80 | LTA4H (0.47) | LTA4HNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8639588 | 0.78 | LTA4H (0.48) | LTA4H | |
| Benzene SCHEMBL8637783 | 0.78 | LTA4H (0.48) | LTA4H | |
| SCHEMBL8639583 | 0.78 | LTA4H (0.46) | LTA4HNPC1RAB9ACYP2C19SMN1; SMN2 | |
| SCHEMBL8637456 | 0.77 | LTA4H (0.46) | LTA4H | |
| SCHEMBL8640787 | 0.77 | LTA4H (0.48) | LTA4HNPC1RAB9A | |
| SCHEMBL8642217 | 0.74 | LTA4H (0.42) | LTA4H | |
| SCHEMBL8641861 | 0.74 | LTA4H (0.47) | LTA4HNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |