SCHEMBL8636154

SCHEMBL8636154

CC(C)Cc1ccc(-c2ccc(CC(C)C)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.53
POLB P06746 1/20 0.53
MAPT P10636 1/20 0.53
KMT2A Q03164 1/20 0.53
PTGS1 P23219 4/20 0.50
PTGS2 P35354 4/20 0.50
LMNA P02545 2/20 0.50
CYP2C9 P11712 2/20 0.50
AKR1C3 P42330 2/20 0.50
CXCR1 P25024 2/20 0.50
CXCR2 P25025 2/20 0.50
AKR1C2 P52895 2/20 0.50
ALB P02768 1/20 0.50
ESR1 P03372 1/20 0.50
ALOX5 P09917 1/20 0.50
RARB P10826 1/20 0.50
ADRB3 P13945 1/20 0.50
NFKB1 P19838 1/20 0.50
HTR2A P28223 1/20 0.50
NR1I3 Q14994 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23319649 0.92 MEN1 (0.53) MEN1POLBMAPTKMT2APTGS1
SCHEMBL1131597 0.91 PTGS1 (0.56) MEN1POLBMAPTKMT2APTGS1
SCHEMBL18725045 0.90 MEN1 (0.47) MEN1POLBMAPTKMT2APTGS1
SCHEMBL15706795 0.90 MEN1 (0.47) MEN1POLBMAPTKMT2APTGS1
SCHEMBL1335887 0.90 TAAR1 (0.50) MEN1POLBMAPTKMT2APTGS1
SCHEMBL25146616 0.88 HRH3 (0.64) MEN1POLBMAPTKMT2APTGS1
SCHEMBL6295424 0.88 MEN1 (0.46) MEN1POLBMAPTKMT2APTGS1
SCHEMBL23696953 0.88 MEN1 (0.46) MEN1POLBMAPTKMT2APTGS1
SCHEMBL19353723 0.88 CYP1A2 (0.53) MEN1POLBMAPTKMT2APTGS1
SCHEMBL25014403 0.88 MEN1 (0.46) MEN1POLBMAPTKMT2APTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119095853-A KRAS inhibitors 伊莱利利公司 2024-12-06 CN disclosed
EP-2838930-A1 POLYMERS CONTAINING SUBSTITUTED OLIGO-TRIARYLAMINE UNITS AND ELECTROLUMINESCENCE DEVICES CONTAINING SUCH POLYMERS Merck Patent GmbH (DE) 2015-02-25 EP disclosed
WO-2013156129-A1 POLYMERS CONTAINING SUBSTITUTED OLIGO-TRIARYLAMINE UNITS AND ELECTROLUMINESCENCE DEVICES CONTAINING SUCH POLYMERS MERCK PATENT GMBH (DE) 2013-10-24 WO disclosed
EP-0504541-B1 Improved catalytic process for selective alkylation of aromatic hydrocarbons SOLUTIA EUROP NV SA (BE) 1998-07-22 EP disclosed
US-5233111-A CATALYTIC PROCESS FOR SELECTIVE ALKYLATION OF AROMATIC HYDROCARBONS MONSANTO COMPANY (US) 1993-08-03 US disclosed
EP-0504541-A1 Improved catalytic process for selective alkylation of aromatic hydrocarbons MONSANTO EUROPE S.A./N.V. (BE) 1992-09-23 EP disclosed
US-4996353-A Process for the preparation of para,para'-polyphenyldicarboxylic acid THE DOW CHEMICAL COMPANY (US) 1991-02-26 US disclosed
EP-0394813-A2 Melt processable thermotropic aromatic copolyesters and process for preparing same THE DOW CHEMICAL COMPANY (US) 1990-10-31 EP disclosed