Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | DRD4 | P21917 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 4/20 | 0.36 |
| ▸ | HRH2 | P25021 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749831 | 0.87 | DRD2 (0.49) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL7753517 | 0.87 | DRD2 (0.49) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL7753532 | 0.87 | DRD2 (0.49) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL8636486 | 0.84 | DRD2 (0.38) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL7753518 | 0.81 | DRD2 (0.44) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL7753554 | 0.78 | DRD2 (0.43) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL7753506 | 0.77 | DRD2 (0.47) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL7755951 | 0.77 | DRD2 (0.47) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL7754653 | 0.77 | DRD2 (0.47) | DRD2DRD4DRD3SIGMAR1HTR2A | |
| SCHEMBL8611421 | 0.77 | TSHR (0.53) | DRD2DRD4DRD3HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833820-A1 | BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039397-A1 | BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-12-12 | — | — | WO | disclosed |