Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11847774 | 0.82 | ALDH1A1 (0.37) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL15665006 | 0.79 | DPP4 (0.52) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL15665598 | 0.78 | ALDH1A1 (0.34) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL2115152 | 0.70 | ALDH1A1 (0.32) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL23145122 | 0.70 | ALDH1A1 (0.46) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL1967099 | 0.70 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL8904306 | 0.69 | ALDH1A1 (0.47) | ALDH1A1LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL1238647 | 0.69 | ALDH1A1 (0.30) | ALDH1A1LMNA | |
| SCHEMBL23043156 | 0.68 | CYP4F2 (0.33) | ALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL5029030 | 0.68 | DPP4 (0.34) | ALDH1A1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783305-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0783518-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| EP-0783305-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009821-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996010035-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |