Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693265 | 0.85 | PTGS2 (0.52) | NPSR1LMNACA12CA1CA2 | |
| SCHEMBL8981360 | 0.78 | PTGS2 (0.58) | CA1CA2CA9PTGS2PTGS1 | |
| SCHEMBL8688579 | 0.77 | PTGS2 (0.64) | NPSR1LMNACA12CA1CA2 | |
| SCHEMBL8639077 | 0.77 | PTGS2 (0.53) | CA9PTGS2PTGS1F10 | |
| SCHEMBL8638997 | 0.76 | PTGS2 (0.52) | NPSR1LMNACA12CA1CA2 | |
| SCHEMBL8639255 | 0.75 | PTGS2 (0.54) | NPSR1LMNACA12CA1CA2 | |
| SCHEMBL7059925 | 0.75 | PTGS2 (0.64) | NPSR1LMNACA12CA1CA2 | |
| SCHEMBL5694290 | 0.74 | PTGS2 (0.65) | LMNACA12CA1CA2CA9 | |
| SCHEMBL8689254 | 0.73 | PTGS2 (0.52) | NPSR1LMNACA12CA1CA2 | |
| SCHEMBL8638981 | 0.73 | F10 (0.48) | PTGS2PTGS1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |