Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634979 | 0.85 | PREP (0.48) | PREP | |
| SCHEMBL8636626 | 0.78 | MEN1 (0.43) | PREPMEN1KMT2A | |
| SCHEMBL7554141 | 0.76 | NOTUM (0.49) | — | |
| SCHEMBL4275949 | 0.76 | NOTUM (0.49) | — | |
| SCHEMBL5002816 | 0.76 | TP53 (0.52) | PREPTP53 | |
| SCHEMBL7300341 | 0.75 | PREP (0.74) | PREP | |
| SCHEMBL4996339 | 0.74 | SMN1; SMN2 (0.51) | MEN1KMT2ATP53 | |
| SCHEMBL4996353 | 0.74 | SMN1; SMN2 (0.51) | MEN1KMT2ATP53 | |
| SCHEMBL5005183 | 0.74 | SMN1; SMN2 (0.51) | MEN1KMT2ATP53 | |
| SCHEMBL7441583 | 0.74 | F2 (0.57) | PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |