Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637353 | 0.78 | PREP (0.44) | MEN1KMT2APREP | |
| SCHEMBL7554141 | 0.78 | NOTUM (0.49) | ALDH1A1NOTUMCYP2C19NPC1CYP1A2 | |
| SCHEMBL4275949 | 0.78 | NOTUM (0.49) | ALDH1A1NOTUMCYP2C19NPC1CYP1A2 | |
| SCHEMBL7549846 | 0.71 | DRD2 (0.53) | ALDH1A1NOTUMDRD2DRD4CYP2C19 | |
| SCHEMBL3247422 | 0.69 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1NOTUMHTT | |
| SCHEMBL8634979 | 0.67 | PREP (0.48) | NPC1RAB9APREP | |
| SCHEMBL14249946 | 0.67 | MEN1 (0.48) | MEN1KMT2AALDH1A1NOTUMCYP2C19 | |
| SCHEMBL30681248 | 0.67 | DRD2 (0.45) | MEN1KMT2AALDH1A1CYP2D6NOTUM | |
| SCHEMBL30681441 | 0.66 | DRD2 (0.53) | ALDH1A1NOTUMDRD2DRD4CYP2C19 | |
| SCHEMBL4289075 | 0.66 | DRD2 (0.53) | ALDH1A1NOTUMDRD2DRD4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |