Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.40 |
| ▸ | PRKDC | P78527 | 5/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | HCK | P08631 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22409699 | 0.75 | SRC (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL7315963 | 0.74 | PIK3CD (0.38) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7317680 | 0.73 | SRC (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL9081191 | 0.71 | PDE4A (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13329771 | 0.70 | SRC (0.47) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7310219 | 0.69 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL863906 | 0.69 | SRC (0.64) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7316083 | 0.68 | KDM4E (0.46) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20500101 | 0.67 | SRC (0.62) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28302069 | 0.67 | CDK1 (0.53) | DPP4ADORA2AADORA1EGFRMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2012-03-29 | — | — | US | claimed |
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | ZAP70, PRKCZ, PRKDC | RET 469/4885DPP4 3737/4885KCNJ6 2149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.