Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635909 | 0.93 | PTGS2 (0.63) | PTGS2PTGS1CYP2C9PDPK1CYP1A2 | |
| SCHEMBL8635490 | 0.90 | PTGS2 (0.80) | PTGS2PTGS1CYP2C9PDPK1CYP1A2 | |
| SCHEMBL8953923 | 0.90 | PTGS2 (0.80) | PTGS2PTGS1CYP2C9PDPK1CYP1A2 | |
| SCHEMBL9003005 | 0.89 | PTGS2 (0.67) | PTGS2PTGS1CYP2C9PDPK1CYP1A2 | |
| SCHEMBL9003046 | 0.89 | PTGS2 (0.82) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL3243753 | 0.88 | PTGS2 (0.82) | PTGS2PTGS1CYP2C9PDPK1CYP3A4 | |
| SCHEMBL9003244 | 0.88 | PTGS2 (0.65) | PTGS2PTGS1CYP2C9PDPK1CYP3A4 | |
| SCHEMBL8635653 | 0.88 | PTGS2 (0.82) | PTGS2PTGS1CYP2C9PDPK1CYP3A4 | |
| SCHEMBL9257388 | 0.88 | PTGS2 (0.81) | PTGS2PTGS1CYP2C9PDPK1 | |
| SCHEMBL9002595 | 0.82 | PTGS2 (0.78) | PTGS2PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731793-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | claimed |
| WO-1995015315-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | claimed |
| EP-0830133-A1 | THERAPEUTIC COMPOSITION FOR ARTHRITIS | Takeda Chemical Industries, Ltd. (JP) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996033717-A1 | THERAPEUTIC COMPOSITION FOR ARTHRITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | disclosed |
| EP-0731793-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5475018-A | Antiinflammatory agent, antiarthritic agent; analgesics and antipyretics | G. D. SEARLE & CO. (US) | 1995-12-12 | — | — | US | disclosed |
| WO-1995015315-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |