⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8190998 | 0.86 | KCNH2 (0.30) | — | |
| SCHEMBL8064354 | 0.86 | KCNH2 (0.30) | — | |
| Potassium SCHEMBL30601758 | 0.84 | — | — | |
| SCHEMBL497067 | 0.76 | — | — | |
| SCHEMBL7738525 | 0.74 | NR1H2 (0.32) | — | |
| SCHEMBL7741481 | 0.74 | NR1H2 (0.32) | — | |
| SCHEMBL7738772 | 0.74 | NR1H2 (0.32) | — | |
| SCHEMBL7739327 | 0.74 | NR1H2 (0.32) | — | |
| SCHEMBL7739429 | 0.74 | NR1H2 (0.32) | — | |
| SCHEMBL8640112 | 0.73 | SLC6A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650474-B1 | NOVEL PIPERIDYL AMIDES, SULFONAMIDES AND SULFOXAMIDES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | MERRELL PHARMA INC (US) | 1998-08-12 | — | — | EP | disclosed |
| US-5489600-A | ANTICHOLESTEROL AND -LIPEMIC AGENTS; ARTERIOSCLEROSIS; ENZYME INHIBIORS | WANNAMAKER MARION W (US) | 1996-02-06 | — | — | US | disclosed |
| US-5350758-A | Anticholesterol agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-27 | — | — | US | disclosed |