Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378108 | 1.00 | ATM (0.55) | ATMGAAMAPTMAPK1LMNA | |
| SCHEMBL7375764 | 0.91 | ATM (0.50) | ATMGAAMAPTMAPK1LMNA | |
| SCHEMBL7376425 | 0.86 | ATM (0.49) | ATMMAPTMAPK1LMNAALDH1A1 | |
| SCHEMBL10757437 | 0.83 | ATM (0.51) | ATMMAPK1HSD17B10ALDH1A1DRD2 | |
| SCHEMBL10757432 | 0.83 | ATM (0.51) | ATMMAPK1HSD17B10ALDH1A1DRD2 | |
| SCHEMBL7370954 | 0.82 | ATM (0.48) | ATMMAPK1LMNAALDH1A1MEN1 | |
| SCHEMBL10757937 | 0.82 | ATM (0.50) | ATMGAAMAPTLMNAHSD17B10 | |
| SCHEMBL10757946 | 0.82 | ATM (0.50) | ATMGAAMAPTLMNAHSD17B10 | |
| SCHEMBL10757943 | 0.82 | ATM (0.50) | ATMGAAMAPTLMNAHSD17B10 | |
| SCHEMBL8635110 | 0.80 | ATM (0.60) | ATMGAAMAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773463-A | DECALCIFICATION OF BRAIN DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-06-30 | — | — | US | disclosed |