Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375674 | 1.00 | ATM (0.60) | ATMSMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL8642023 | 0.87 | ATM (0.49) | ATMSMN1; SMN2DRD2MEN1KMT2A | |
| SCHEMBL8642025 | 0.87 | ATM (0.49) | ATMSMN1; SMN2DRD2MEN1KMT2A | |
| SCHEMBL8642019 | 0.87 | ATM (0.49) | ATMSMN1; SMN2DRD2MEN1KMT2A | |
| SCHEMBL14143095 | 0.83 | ATM (0.68) | ATMSMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL7328550 | 0.82 | EPHX2 (0.49) | ATMSMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL8635461 | 0.82 | EPHX2 (0.49) | ATMSMN1; SMN2NFKB1NFKB2RELA | |
| SCHEMBL10920653 | 0.81 | PYGL (0.42) | ATMMAPK1TSHRMEN1KMT2A | |
| SCHEMBL4707056 | 0.81 | PYGL (0.42) | ATMMAPK1TSHRMEN1KMT2A | |
| SCHEMBL8639617 | 0.80 | ATM (0.55) | ATMSMN1; SMN2NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773463-A | DECALCIFICATION OF BRAIN DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-06-30 | — | — | US | disclosed |
| US-4638066-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1987-01-20 | — | — | US | disclosed |
| EP-0088575-B1 | PENTACYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1986-12-30 | — | — | EP | disclosed |
| US-4585588-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1986-04-29 | — | — | US | disclosed |
| EP-0154298-A2 | Treatment of diarrhoea | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |
| US-4504480-A | DIAZABENZOCYCLOHEPTAFLUORENE DERIVATRIVES, ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1985-03-12 | — | — | US | disclosed |
| EP-0088575-A2 | Pentacyclic compounds | BEECHAM GROUP PLC (GB) | 1983-09-14 | — | — | EP | disclosed |