Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868758 | 0.89 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL8640765 | 0.88 | PTGS1 (0.51) | PTGS2PDPK1PTGS1FFAR4 | |
| SCHEMBL8351386 | 0.86 | PTGS2 (0.49) | PTGS2PDPK1PTGS1 | |
| SCHEMBL8641577 | 0.86 | PTGS2 (0.49) | PTGS2PDPK1PTGS1 | |
| SCHEMBL8640008 | 0.86 | PTGS2 (0.55) | PTGS2PDPK1PTGS1KAT6AALPI | |
| SCHEMBL8639795 | 0.85 | PTGS2 (0.50) | PTGS2PDPK1PTGS1MALT1 | |
| SCHEMBL8643571 | 0.85 | PTGS2 (0.51) | PTGS2PDPK1PTGS1FFAR4 | |
| SCHEMBL6514097 | 0.85 | PTGS2 (0.50) | PTGS2PDPK1PTGS1 | |
| SCHEMBL8638817 | 0.85 | PTGS2 (0.46) | PTGS2PDPK1PTGS1 | |
| SCHEMBL7135445 | 0.85 | PTGS2 (0.51) | PTGS2PDPK1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |