Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.56 |
| ▸ | LCK | P06239 | 3/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.52 |
| ▸ | PRKDC | P78527 | 13/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 14/20 | 0.50 |
| ▸ | ABL1 | P00519 | 13/20 | 0.50 |
| ▸ | EGFR | P00533 | 13/20 | 0.50 |
| ▸ | SRC | P12931 | 13/20 | 0.50 |
| ▸ | HCK | P08631 | 12/20 | 0.50 |
| ▸ | MTOR | P42345 | 12/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL863581 | 0.89 | ABL1 (0.57) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL17090620 | 0.88 | LCK (0.69) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL863295 | 0.87 | CSNK1A1 (0.60) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL864640 | 0.87 | BTK (0.56) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL14617692 | 0.87 | BTK (0.60) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL13019968 | 0.85 | CSNK1A1 (0.60) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL17090619 | 0.84 | LCK (0.76) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL14617701 | 0.83 | BTK (0.38) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL23259873 | 0.83 | CSNK1A1 (0.62) | BTKLCKLYNPIK3CDPIK3CA | |
| SCHEMBL14617691 | 0.83 | LCK (0.67) | BTKLCKLYNPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2012-03-29 | — | — | US | claimed |
| US-9862722-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2018-01-09 | — | — | US | disclosed |
| US-20150329550-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2015-11-19 | — | — | US | disclosed |
| US-9138436-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2015-09-22 | — | — | US | disclosed |
| US-8642606-B2 | ZAP-70 active compounds | PLEXXIKON INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642606-B2 | ZAP-70 active compounds | PLEXXIKON INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642606-B2 | ZAP-70 active compounds | PLEXXIKON INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20130018032-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2012-03-29 | — | — | US | disclosed |
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2012-03-29 | — | — | US | disclosed |
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | PLEXXIKON, INC. | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329550-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885LCK 19/4885LYN 6/4885 |
| US-20120077827-A1 | ZAP-70 ACTIVE COMPOUNDS | ZAP70, PRKCZ, PRKDC | BTK 13/4885LCK 4/4885LYN 15/4885 |
| US-20130018032-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885LCK 19/4885LYN 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.