Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622465 | 0.87 | THRA (0.66) | THRATHRBSIRT3 | |
| SCHEMBL8642126 | 0.84 | THRA (0.49) | THRATHRBSIRT3PTPN1 | |
| SCHEMBL8621626 | 0.80 | THRA (0.68) | THRATHRBSIRT3 | |
| SCHEMBL8620054 | 0.80 | THRA (0.65) | THRATHRBSIRT3 | |
| SCHEMBL8624400 | 0.80 | THRA (0.49) | THRATHRBSIRT3 | |
| SCHEMBL8642130 | 0.74 | THRA (0.50) | THRATHRBSIRT3PTPN1 | |
| SCHEMBL8655206 | 0.74 | THRA (0.71) | THRATHRBSIRT3 | |
| SCHEMBL8619765 | 0.73 | THRA (0.67) | THRATHRBSIRT3 | |
| SCHEMBL8623690 | 0.72 | THRA (0.50) | THRATHRBSIRT3 | |
| SCHEMBL9422389 | 0.72 | THRA (0.58) | THRATHRBSIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |