Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.58 |
| ▸ | EBP | Q15125 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | PGR | P06401 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770194 | 1.00 | ESR1 (0.58) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8613926 | 0.94 | ESR1 (0.63) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8639615 | 0.94 | ESR1 (0.63) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8639612 | 0.94 | ESR1 (0.63) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8639618 | 0.94 | ESR1 (0.63) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8644016 | 0.93 | ESR1 (0.62) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8644018 | 0.93 | ESR1 (0.62) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8644014 | 0.93 | ESR1 (0.62) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL8770160 | 0.89 | ESR1 (0.55) | ESR1ESR2CYP19A1EBPKMT2A | |
| SCHEMBL17152214 | 0.86 | CYP19A1 (0.81) | ESR1ESR2CYP19A1EBPKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720597-B1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMA INC (US) | 1998-04-29 | — | — | EP | disclosed |
| EP-0794771-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0720597-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| US-5525633-A | ANTITUMOR AGENTS, ANTICHOLESTEROL AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1996016646-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1995008528-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-30 | — | — | WO | disclosed |