Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 16/20 | 0.81 |
| ▸ | ESR1 | P03372 | 14/20 | 0.81 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.67 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | EBP | Q15125 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | IDH1 | O75874 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17470686 | 0.94 | CYP19A1 (0.69) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL8642207 | 0.86 | ESR1 (0.58) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL8770194 | 0.86 | ESR1 (0.58) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL22995790 | 0.81 | CYP19A1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL28404807 | 0.81 | CYP19A1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL24302096 | 0.81 | CYP19A1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL10379044 | 0.81 | ESR1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL18284450 | 0.81 | ESR1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL10108163 | 0.81 | ESR1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL8612298 | 0.80 | ESR1 (0.64) | ESR1ESR2CYP3A4CYP2D6EBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687458-B2 | Trans-clomiphene for use in cancer therapy | REPROS THERAPEUTICS INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-9616034-B2 | Trans-clomiphene and its analogues as agents that increase bone mineral density | REPROS THERAPEUTICS INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-20160128953-A1 | TRANS-CLOMIPHENE AND ITS ANALOGUES AS AGENTS THAT INCREASE BONE MINERAL DENSITY | REPROS THERAPEUTICS INC. (US) | 2016-05-12 | — | — | US | disclosed |
| US-20150283099-A1 | Trans-Clomiphene for Use in Cancer Therapy | REPROS THERAPEUTICS INC. (US) | 2015-10-08 | — | — | US | disclosed |