Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.69 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.69 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.63 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599570 | 0.91 | GPBAR1 (0.82) | CYSLTR1GPBAR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL9129064 | 0.89 | GPBAR1 (0.82) | CYSLTR1GPBAR1FFAR1AKR1B1ALOX5 | |
| Acetic Acid SCHEMBL9428160 | 0.85 | GPBAR1 (0.76) | CYSLTR1GPBAR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL7457682 | 0.85 | GPBAR1 (0.90) | CYSLTR1GPBAR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL7718896 | 0.85 | GPBAR1 (0.90) | CYSLTR1GPBAR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL7452285 | 0.83 | CYSLTR1 (0.77) | CYSLTR1GPBAR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL7711072 | 0.82 | GPBAR1 (0.80) | CYSLTR1GPBAR1ALOX5CYSLTR2 | |
| SCHEMBL8734219 | 0.82 | CYSLTR1 (1.00) | CYSLTR1GPBAR1 | |
| SCHEMBL26771305 | 0.82 | GPBAR1 (0.83) | CYSLTR1GPBAR1FFAR1AKR1B1ALOX5 | |
| SCHEMBL421067 | 0.82 | GPBAR1 (1.00) | CYSLTR1GPBAR1FFAR1AKR1B1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783586-A | Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| WO-1998014429-A1 | HETEROARYLMETHOXYPHENYLTHIOALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1998-04-09 | — | — | WO | disclosed |