Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.82 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.69 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9129064 | 0.97 | GPBAR1 (0.82) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| Acetic Acid SCHEMBL9428160 | 0.93 | GPBAR1 (0.76) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL8644286 | 0.91 | CYSLTR1 (0.69) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL421067 | 0.90 | GPBAR1 (1.00) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9581618 | 0.89 | GPBAR1 (0.97) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL3271764 | 0.89 | GPBAR1 (0.78) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9130161 | 0.89 | GPBAR1 (0.78) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL3270032 | 0.89 | GPBAR1 (0.78) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9581634 | 0.89 | GPBAR1 (0.97) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL9045246 | 0.87 | GPBAR1 (0.80) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | disclosed |
| US-5843968-A | Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-12-01 | — | — | US | disclosed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | disclosed |
| US-5783586-A | Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| WO-1998014429-A1 | HETEROARYLMETHOXYPHENYLTHIOALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1998-04-09 | — | — | WO | disclosed |
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | disclosed |
| US-5668146-A | ANTIINFLAMMATORY AGENTS OR ANTIALLERGENS | ABBOTT LABORATORIES (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1997012866-A1 | BIS-HETEROARYLYLMETHOXYPHENYLKETONE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | disclosed |