SCHEMBL8645016

SCHEMBL8645016

CCON=C(C(=O)OCC)c1csc(N)n1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.63
MEN1 O00255 9/20 0.63
KMT2A Q03164 9/20 0.63
ALDH1A1 P00352 3/20 0.63
NPC1 O15118 1/20 0.63
RAB9A P51151 1/20 0.63
TDP1 Q9NUW8 4/20 0.55
L3MBTL1 Q9Y468 3/20 0.55
MAPK1 P28482 3/20 0.55
LMNA P02545 2/20 0.55
GAA P10253 3/20 0.44
NPSR1 Q6W5P4 3/20 0.44
RECQL P46063 1/20 0.44
HTT P42858 3/20 0.43
KDM4E B2RXH2 1/20 0.43
PKM P14618 1/20 0.43
HPGD P15428 2/20 0.42
TSHR P16473 2/20 0.42
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8645013 1.00 MAPT (0.63) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL10538827 1.00 MAPT (0.63) MAPTMEN1KMT2AALDH1A1NPC1
Bromide SCHEMBL9075332 0.99 MAPT (0.62) MAPTMEN1KMT2AALDH1A1NPC1
Bromide SCHEMBL9075329 0.99 MAPT (0.62) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL8662279 0.91 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL8647744 0.91 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL10418508 0.91 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL8662287 0.91 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL10554790 0.91 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL10554800 0.91 MAPT (0.59) MAPTMEN1KMT2AALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5247013-A None JP disclosed
EP-0859002-A1 Process for producing chloroacetylaminothiazoleacetic acid derivatives TOKUYAMA CORPORATION (JP) 1998-08-19 EP disclosed
US-5336776-A Cephalopsporin intermediates; Staphyloccus septicemia and skin disorders; penicillin-resistant gramnegative bacteria ROUSSEL UCLAF (FR) 1994-08-09 US disclosed
JP-H05247013-A NOVEL OXIME DERIVATIVE OF AMINOTHIAZOLYL ACETIC ACID AND PREPARATION THEREOF ROUSSEL UCLAF 1993-09-24 JP disclosed
US-5103012-A Chemical intermediate ROUSSEL UCLAF (FR) 1992-04-07 US disclosed
US-4988816-A Chemical intermediates for cephalosporin antibiotics ROUSSEL UCLAF (FR) 1991-01-29 US disclosed
US-4923998-A ANTIBIOTICS FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1990-05-08 US disclosed
US-4843164-A CEPHALOSPORIN INTERMEDIATE; ANTIBIOTIC ROUSSEL UCLAF (FR) 1989-06-27 US disclosed
US-4841062-A CHEMICAL INTERMEDIATES FUJISAWA PHARMACEUTICAL COMPANY, LIMITED (JP) 1989-06-20 US disclosed
US-4822888-A INTERMEDIATES FOR CEPHALOSPORIN ANTIBIOTICS FUJISAWA PHARMACEUTICAL COMPANY, LIMITED (JP) 1989-04-18 US disclosed
US-4399131-A Cephem derivatives HOECHST AG (DE) 1983-08-16 US disclosed
US-4399133-A ADMINISTERING, INFECTIONS FUJISAWA PHARMACEUTICAL COMPANY, LIMITED (JP) 1983-08-16 US disclosed
US-4393059-A BACTERICIDAL CEPHALOSPORINS FUJISAWA PHARMACEUTICAL COMPANY, LIMITED (JP) 1983-07-12 US disclosed
US-4376203-A ANTIBIOTIC ROUSSELL UCLAF (FR) 1983-03-08 US disclosed
US-4304770-A Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-12-08 US disclosed
US-4294960-A 7-[2-(2-Aminothiazol-4-yl)-2-cyclopentyloxyiminoacetamido]-3-cephem-4-carboxylic acid (synisomer) FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-10-13 US disclosed
US-4288436-A ANTIBIOTICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1981-09-08 US disclosed
US-4283396-A 3-Acetoxymethyl-7-(hydroxyiminoacetamido)-cephalosporanic acid derivatives ROUSSEL UCLAF (FR) 1981-08-11 US disclosed
US-4196205-A ANTIBIOTICS, BACTERICIDES ROUSSEL UCLAF (FR) 1980-04-01 US disclosed
US-4152432-A ANTIBIOTICS ROUSSEL UCLAF (FR) 1979-05-01 US disclosed