Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | UBE2N | P61088 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8642267 | 0.88 | LMNA (0.55) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8649791 | 0.88 | LMNA (0.50) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8648397 | 0.87 | LMNA (0.54) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7010532 | 0.84 | LMNA (0.69) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8645180 | 0.82 | HTT (0.49) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8643199 | 0.82 | LMNA (0.55) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8649860 | 0.82 | LMNA (0.55) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8645114 | 0.81 | LMNA (0.54) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8643383 | 0.81 | LMNA (0.54) | LMNAMAPK1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8644499 | 0.81 | LMNA (0.51) | LMNAMAPK1HTTMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |