Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8646878 | 0.91 | LMNA (0.46) | LMNAMAPK1SMN1; SMN2MAPTTRPC5 | |
| SCHEMBL8645652 | 0.90 | LMNA (0.45) | LMNAMAPK1SMN1; SMN2MAPTTRPC5 | |
| SCHEMBL8642267 | 0.88 | LMNA (0.55) | LMNAMAPK1SMN1; SMN2MAPTHTT | |
| SCHEMBL8642085 | 0.88 | LMNA (0.43) | LMNAMAPK1SMN1; SMN2MAPTTRPC5 | |
| Hydrochloric Acid SCHEMBL8648397 | 0.87 | LMNA (0.54) | LMNAMAPK1SMN1; SMN2MAPTHTT | |
| SCHEMBL8643702 | 0.84 | LMNA (0.46) | LMNAMAPK1SMN1; SMN2MAPTHTT | |
| SCHEMBL7012058 | 0.83 | LMNA (0.65) | LMNAMAPK1SMN1; SMN2TRPC5HTT | |
| SCHEMBL8643969 | 0.82 | SMN1; SMN2 (0.44) | LMNAMAPK1SMN1; SMN2TP53TDP1 | |
| SCHEMBL8645114 | 0.81 | LMNA (0.54) | LMNAMAPK1SMN1; SMN2MAPTHTT | |
| SCHEMBL8645180 | 0.80 | HTT (0.49) | LMNAMAPK1SMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |