SCHEMBL8645642

SCHEMBL8645642

CC(O[Si](C)(C)C(C)(C)C)[C@@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(OP(=O)(c3ccccc3)c3ccccc3)[C@H](C)[C@H]12

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PLCG1 P19174 1/20 0.38
RAB9A P51151 1/20 0.35
ELANE P08246 7/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
TDP1 Q9NUW8 1/20 0.33
POLB P06746 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10382583 1.00 PLCG1 (0.38) PLCG1RAB9AELANEL3MBTL1TDP1
SCHEMBL8645639 1.00 PLCG1 (0.38) PLCG1RAB9AELANEL3MBTL1TDP1
SCHEMBL9026674 0.93 PLCG1 (0.40) PLCG1RAB9AELANEL3MBTL1TDP1
SCHEMBL8641365 0.92 ELANE (0.41) ELANE
SCHEMBL8641363 0.92 ELANE (0.41) ELANE
SCHEMBL9042014 0.88 PLCG1 (0.40) PLCG1RAB9AELANEL3MBTL1TDP1
SCHEMBL9664427 0.87 PLCG1 (0.42) PLCG1RAB9AELANEL3MBTL1TDP1
SCHEMBL7593231 0.87 PLCG1 (0.42) PLCG1RAB9AELANEL3MBTL1TDP1
SCHEMBL9640039 0.87 PLCG1 (0.42) PLCG1RAB9AELANEL3MBTL1TDP1
SCHEMBL9640033 0.87 PLCG1 (0.42) PLCG1RAB9AELANEL3MBTL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0679652-B1 Process for preparing carbapenem compounds SUMITOMO PHARMA (JP) 1998-08-19 EP disclosed
US-5578722-A Process for preparing carbapenem compounds SUMITOMO PHARMACEUTICALS CO., LTD. (JP) 1996-11-26 US disclosed
EP-0679652-A1 Process for preparing carbapenem compounds SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1995-11-02 EP disclosed