Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 4/20 | 0.53 |
| ▸ | HTR1D | P28221 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7542995 | 0.99 | HTR1B (0.68) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8649162 | 0.99 | HTR1B (0.71) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7540490 | 0.98 | HTR1B (0.69) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7408877 | 0.83 | HTR1F (0.59) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1200009 | 0.82 | HTR1B (1.00) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL15281757 | 0.82 | HTR1B (1.00) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL13152879 | 0.82 | HTR1B (1.00) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2359775 | 0.79 | HTR1B (0.76) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL14258623 | 0.78 | CNR1 (0.83) | MAPTSMN1; SMN2CNR1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL9266080 | 0.78 | HTR1B (0.74) | HTR1BMAPTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603432-B1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1998-10-21 | — | — | EP | claimed |
| EP-0591280-B1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-09-09 | — | — | EP | claimed |
| EP-0603432-A1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | claimed |
| EP-0591280-A1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000086-A1 | USE OF TETRAHYDROCARBAZONE DERIVATIVES AS 5HT1 RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-01-07 | — | — | WO | claimed |