Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.60 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.56 |
| ▸ | GNPAT | O15228 | 1/20 | 0.53 |
| ▸ | CPA3 | P15088 | 1/20 | 0.53 |
| ▸ | MME | P08473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL8643183 | 1.00 | NAALAD2 (0.60) | NAALAD2SLC15A1GNPATCPA3MME | |
| SCHEMBL93439 | 0.93 | GNPAT (0.58) | NAALAD2GNPATMMENPSR1ALPI | |
| SCHEMBL93440 | 0.93 | GNPAT (0.58) | NAALAD2GNPATMMENPSR1ALPI | |
| SCHEMBL412958 | 0.93 | GNPAT (0.58) | NAALAD2GNPATMMENPSR1ALPI | |
| SCHEMBL5694618 | 0.93 | GNPAT (0.58) | NAALAD2GNPATMMENPSR1ALPI | |
| Malonic Acid SCHEMBL8644619 | 0.91 | GNPAT (0.55) | NAALAD2GNPATCPA3MMENPSR1 | |
| Hydrochloric Acid SCHEMBL27197703 | 0.91 | GNPAT (0.57) | NAALAD2GNPATMMENPSR1ALPI | |
| Oxalic Acid SCHEMBL8649953 | 0.89 | GNPAT (0.56) | NAALAD2GNPATMMENPSR1ALPI | |
| Formic Acid SCHEMBL30065163 | 0.86 | GNPAT (0.53) | NAALAD2GNPATMMENPSR1ALPI | |
| Maleic Acid SCHEMBL8645722 | 0.85 | SLC15A1 (0.54) | NAALAD2SLC15A1GNPATMMENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5820881-A | BIOLOGICALLY AND CHEMICALLY ACTIVE AGENTS, ENZYME INHIBITOR, EXCIPIENT, DILUENT, LUBRICANT, DISINTEGRANT, PLASTICIZER COLORANT AND DOSAGE VEHICLE | EMISPHERE TECHNOLOGIES, INC. (US) | 1998-10-13 | — | — | US | disclosed |