SLC15A1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Phenylalanine (SCHEMBL744817)	0.71	3/20
SCHEMBL1067018	0.53	3/20
SCHEMBL1067021	0.53	3/20
SCHEMBL215141	0.51	3/20
SCHEMBL883466	0.66	2/20
SCHEMBL995791	0.66	2/20
SCHEMBL996112	0.66	2/20
SCHEMBL997986	0.66	2/20
SCHEMBL1241916	0.65	2/20
SCHEMBL730848	0.65	2/20
SCHEMBL84418	0.63	2/20
SCHEMBL589202	0.61	2/20
SCHEMBL589203	0.61	2/20
SCHEMBL1264374	0.61	2/20
SCHEMBL73707	0.60	2/20
SCHEMBL73708	0.60	2/20
SCHEMBL111390	0.58	2/20
Hydrochloric Acid (SCHEMBL353729)	0.58	2/20
Hydrochloric Acid (SCHEMBL1168587)	0.58	2/20
SCHEMBL288607	0.58	2/20

Clinical trials — most relevant to SLC15A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Age on the Renal Clearance of Adefovir	PHASE4	WITHDRAWN
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD	PHASE3	COMPLETED
A Study Comparing CO-1.01 With Gemcitabine as First Line Therapy in Patients With Metastatic Pancreatic Adenocarcinoma (LEAP)	PHASE2	COMPLETED
Intrathecal Gene Therapy For SLC13A5 Citrate Transporter Disorder	PHASE1/PHASE2	NOT_YET_RECRUITING
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia	PHASE1/PHASE2	RECRUITING
THE EFFECT OF CYP3A5 GENOTYPE ON THE PHARMACOKINETICS OF MARAVIROC	PHASE1	COMPLETED
Statin Therapy to Improve Medication Adherence	PHASE1	COMPLETED
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Pharmacokinetics (PK) Study of Once Daily Darunavir/Ritonavir and Twice and Once Daily Raltegravir in HIV-infected Subjects	PHASE1	COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer	EARLY_PHASE1	UNKNOWN
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
SLC13A5 Deficiency Natural History Study - Remote Only	nan	ENROLLING_BY_INVITATION
Understanding Methotrexate Induced Gastrointestinal Intolerance in Juvenile Idiopathic Arthritis and Childhood Leukemia	nan	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors	nan	UNKNOWN
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs	nan	COMPLETED
ADPKD Alterations in Hepatic Transporter Function	nan	COMPLETED
Effect of SLC01B1 (rs4149956) Polymorphism on the Efficacy and Tolerability of Atorvastatin in Pakistani Population	nan	COMPLETED
Bile Acid Effects in Fetal Arrhythmia Study	nan	UNKNOWN
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
Role of the ATP7A Transporter in Ovarian Cancer	nan	COMPLETED
SLC13A5 Deficiency Natural History Study - United States Only	nan	ENROLLING_BY_INVITATION
Effect of SLC01B1 (rs2306283) Polymorphism on the Efficacy and Safety Profile of Atorvastatin in Pakistani Population	nan	COMPLETED
Evaluation of HPGD and SCLO2A1 Expression in Clear Cell Renal Cell Carcinoma Patients	nan	COMPLETED
Characterization of Breg Cells	nan	COMPLETED
Renal and Hepatic Clearance Following High-Dose Methotrexate in Childhood ALL	nan	COMPLETED
Integrating Pharmacogenetics In Clinical Care	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC15A1 binder may also engage these)

Protein	Name	Similarity
P36836	—	1.000	P36836 →
Q8WMX5	—	1.000	Q8WMX5 →
Q9JIP7	—	0.999	Q9JIP7 →
P46029	—	0.996	P46029 →
B0S6T2	—	0.994	B0S6T2 →
P51574	—	0.993	P51574 →
SLC15A2	Solute carrier family 15 member 2	0.988	landscape →
Q9ES07	—	0.983	Q9ES07 →
Q63424	—	0.980	Q63424 →
O23596	—	0.979	O23596 →
SLC33A1	Acetyl-coenzyme A transporter 1	0.976	landscape →
Q9SA71	—	0.976	Q9SA71 →
Q21219	—	0.974	Q21219 →
Q6AYY8	—	0.974	Q6AYY8 →
Q99J27	—	0.973	Q99J27 →
P49283	—	0.972	P49283 →
Q9SB41	—	0.972	Q9SB41 →
Q8BLE7	—	0.971	Q8BLE7 →
Q39231	—	0.971	Q39231 →
P55016	—	0.971	P55016 →
Q17758	—	0.971	Q17758 →
P91679	—	0.969	P91679 →
Q9FG00	—	0.969	Q9FG00 →
Q9Y115	—	0.969	Q9Y115 →
Q03411	—	0.968	Q03411 →
Q869V1	—	0.968	Q869V1 →
Q9I9M5	—	0.967	Q9I9M5 →
Q1L8X9	—	0.967	Q1L8X9 →
Q09143	—	0.967	Q09143 →
Q9ZVK6	—	0.967	Q9ZVK6 →