Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | KIF5B | P33176 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052816 | 0.98 | EGFR (0.66) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8649000 | 0.91 | EGFR (0.73) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8650199 | 0.88 | EGFR (0.49) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8648185 | 0.88 | EGFR (0.62) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8649983 | 0.87 | EGFR (0.64) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL7966368 | 0.84 | EGFR (0.63) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8652205 | 0.84 | EGFR (0.60) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8645752 | 0.83 | EGFR (0.62) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8657810 | 0.83 | EGFR (0.58) | EGFRCSF1RRETKIF5BKDR | |
| Lithium SCHEMBL9114231 | 0.83 | EGFR (0.59) | EGFRCSF1RRETKIF5BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736534-A | HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA | PFIZER INC. (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0746554-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |