Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.63 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | KIF5B | P33176 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | BACE1 | P56817 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8649000 | 0.88 | EGFR (0.73) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8649983 | 0.86 | EGFR (0.64) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL9052816 | 0.84 | EGFR (0.66) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8647145 | 0.84 | EGFR (0.62) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8648433 | 0.83 | EGFR (0.76) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8652205 | 0.82 | EGFR (0.60) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8648185 | 0.82 | EGFR (0.62) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL4352943 | 0.81 | EGFR (0.48) | EGFRCSF1R | |
| SCHEMBL8645752 | 0.80 | EGFR (0.62) | EGFRCSF1RRETKDRKIF5B | |
| SCHEMBL8657810 | 0.80 | EGFR (0.58) | EGFRCSF1RRETKDRKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |