Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4773698 | 0.83 | MEN1 (0.51) | MEN1KMT2AMMP13POLBGPR119 | |
| SCHEMBL4773466 | 0.80 | TP53 (0.54) | MEN1KMT2AMMP13POLBGPR119 | |
| SCHEMBL8647537 | 0.80 | BRD3 (0.45) | MEN1KMT2AMMP13POLBGPR119 | |
| SCHEMBL4139902 | 0.80 | DNMT3A (0.56) | MEN1KMT2AMMP13GPR119DNMT3A | |
| SCHEMBL4152084 | 0.79 | MAOB (0.52) | MEN1KMT2AMMP13GPR119 | |
| SCHEMBL20002917 | 0.79 | MEN1 (0.47) | MEN1KMT2AMMP13POLBGPR119 | |
| SCHEMBL13590834 | 0.78 | GPR119 (0.52) | MEN1KMT2AMMP13POLBGPR119 | |
| SCHEMBL8647868 | 0.78 | MEN1 (0.51) | MEN1KMT2AMMP13POLBGPR119 | |
| SCHEMBL7495934 | 0.78 | MEN1 (0.48) | MEN1KMT2AMMP13POLBGPR119 | |
| SCHEMBL7495483 | 0.77 | KMT2A (0.50) | MEN1KMT2AMMP13GPR119DNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |
| EP-0804434-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004274-A1 | AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-15 | — | — | WO | disclosed |