SCHEMBL8648199

SCHEMBL8648199

O=C(O)C(=Cc1ccccc1F)c1cccnc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
APP P05067 1/20 0.47
GAA P10253 1/20 0.47
HCAR3 P49019 1/20 0.47
HCAR2 Q8TDS4 1/20 0.47
CYP1A2 P05177 3/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HIF1A Q16665 1/20 0.47
PLOD2 O00469 1/20 0.45
POLB P06746 1/20 0.45
TBXAS1 P24557 3/20 0.44
CYP1A1 P04798 2/20 0.44
CYP1B1 Q16678 2/20 0.44
CYP2D6 P10635 1/20 0.44
LMNA P02545 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8648195 1.00 ALDH1A1 (0.47) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8648112 0.83 ALDH1A1 (0.60) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8643722 0.83 ALDH1A1 (0.47) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8648115 0.83 ALDH1A1 (0.60) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8643718 0.83 ALDH1A1 (0.47) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8647082 0.82 ALDH1A1 (0.46) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8647088 0.82 ALDH1A1 (0.46) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8646793 0.81 ATM (0.57) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8646796 0.81 ATM (0.57) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL8646375 0.80 AKR1C1 (0.68) ALDH1A1APPGAAHCAR3HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861831-A1 HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1998-09-02 EP disclosed