SCHEMBL8648588

SCHEMBL8648588

C=CCC1=C(O)C(=O)C(CC=C)O1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 1/20 0.31
SLC2A1 P11166 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11497992 0.80 SLC2A1 (0.31) SLC2A1
SCHEMBL8153153 0.71 SLC2A1 (0.35) SLC2A1
SCHEMBL242884 0.65 PRSS1 (0.41) SLC2A1
SCHEMBL9818508 0.62 SLC2A1 (0.33) SLC2A1
SCHEMBL8756026 0.62 SLC2A1 (0.36) SLC2A1
SCHEMBL5971892 0.62
SCHEMBL8651815 0.60 TYR (0.42) SRD5A1
SCHEMBL8243272 0.60
SCHEMBL3185827 0.60 PRSS1 (0.38) SLC2A1
SCHEMBL8753094 0.58 NR1H4 (0.31) SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0532120-A1 Process for the preparation of 4-hydroxy-3(2H)furanones Tastemaker B.V. (NL) 1993-03-17 EP claimed
EP-0055976-B1 PROCESS FOR PREPARING 2,5-DIALKYL-4-HYDROXY-3(2H)-FURANONES AND 4-ALKENYL-DIHYDRO-3(2H) FURANONES OBTAINED AS INTERMEDIATE PRODUCTS ISTITUTO PER LA RICERCA SCIENTIFICA E APPLICATA DI TECNOLOGIE ALIMENTARI S.p.A. (IT) 1984-08-08 EP claimed
EP-0055976-A1 Process for preparing 2,5-dialkyl-4-hydroxy-3(2H)-furanones and 4-alkenyl-dihydro-3(2H) furanones obtained as intermediate products ISTITUTO PER LA RICERCA SCIENTIFICA E APPLICATA DI TECNOLOGIE ALIMENTARI S.p.A. (IT) 1982-07-14 EP claimed
US-4294767-A Process for the preparation of 2,5-dimethyl-4-hydroxy-3(2H)-furanone and its 2,5-dialkyl homologues INSTITUTO PER LA RICERCA SCIENTIFICA E APPLICATA DI TECHNOLOGIE ALIMENTARI S.P.A (IT) 1981-10-13 US claimed
US-4139649-A ROAST BEEF INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1979-02-13 US claimed
US-4127592-A Process of the preparation of hydroxyfurenones POLAK'S FRUTAL WORKS, B.V. (NL) 1978-11-28 US claimed
JP-5194461-A None JP disclosed
EP-0532120-B1 Process for the preparation of 4-hydroxy-3(2H)furanones TASTEMAKER BV (NL) 1998-01-07 EP disclosed
US-5412121-A Process for the preparation of 4-hydroxy-3[2H]furanones TASTEMAKER (US) 1995-05-02 US disclosed
US-5412121-A Process for the preparation of 4-hydroxy-3[2H]furanones TASTEMAKER (US) 1995-05-02 US disclosed
JP-H05194461-A 4-HYDROXY-3(2H)FURANONES PFW FLAVORS BV 1993-08-03 JP disclosed
EP-0532120-A1 Process for the preparation of 4-hydroxy-3(2H)furanones Tastemaker B.V. (NL) 1993-03-17 EP disclosed
EP-0532120-A1 Process for the preparation of 4-hydroxy-3(2H)furanones Tastemaker B.V. (NL) 1993-03-17 EP disclosed
US-4294767-A Process for the preparation of 2,5-dimethyl-4-hydroxy-3(2H)-furanone and its 2,5-dialkyl homologues INSTITUTO PER LA RICERCA SCIENTIFICA E APPLICATA DI TECHNOLOGIE ALIMENTARI S.P.A (IT) 1981-10-13 US disclosed
US-4250101-A Bis-epoxy-dialkoxy-alkanes BASF AKTIENGESELLSCHAFT (DE) 1981-02-10 US disclosed
US-4189439-A FLAVORANTS POLAK'S FRUTAL WORKS, B.V. (NL) 1980-02-19 US disclosed
US-4139649-A ROAST BEEF INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1979-02-13 US disclosed
US-4127592-A Process of the preparation of hydroxyfurenones POLAK'S FRUTAL WORKS, B.V. (NL) 1978-11-28 US disclosed
US-4070381-A FLAVOR IMPROVERS LEVER BROTHERS COMPANY (US) 1978-01-24 US disclosed
US-3950565-A 4-HYDROXY-2-FUREN-3-ONES LEVER BROTHERS COMPANY (US) 1976-04-13 US disclosed