Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP19 | O94966 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16101520 | 0.92 | OPRD1 (0.48) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL12492182 | 0.85 | OPRD1 (0.43) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL5520738 | 0.84 | JAK2 (0.50) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL12493077 | 0.84 | ATM (0.45) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL13277303 | 0.83 | OPRD1 (0.45) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL16827186 | 0.81 | TACR1 (0.48) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL12492823 | 0.81 | OPRD1 (0.46) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL2951728 | 0.79 | OPRD1 (0.53) | OPRD1OPRK1TSHRALOX15TACR1 | |
| SCHEMBL27313194 | 0.78 | OPRD1 (0.47) | OPRD1OPRK1JAK2JAK1TSHR | |
| SCHEMBL22834092 | 0.77 | OPRD1 (0.51) | OPRD1OPRK1TSHRALOX15TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |