⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650091 | 1.00 | — | — | |
| Cadaverine Tartrate SCHEMBL28860820 | 0.81 | TSHR (0.56) | — | |
| SCHEMBL765683 | 0.80 | CHRM1 (0.48) | — | |
| SCHEMBL15609557 | 0.80 | CHRM1 (0.48) | — | |
| SCHEMBL28444248 | 0.80 | CHRM1 (0.48) | — | |
| SCHEMBL417500 | 0.80 | CHRM1 (0.48) | — | |
| SCHEMBL29957876 | 0.80 | CHRM1 (0.48) | — | |
| SCHEMBL15609874 | 0.80 | CHRM1 (0.48) | — | |
| Cadaverine Tartrate SCHEMBL11872744 | 0.79 | TSHR (0.53) | — | |
| SCHEMBL14753844 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672648-A1 | Threo-3-amino-2-hydroxypentanoic acid and threo (2R,3S), (2S,3R)-3-(p-methoxy-benzyloxycarbonyl) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1995-09-20 | — | — | EP | claimed |
| JP-4001162-A | — | — | None | — | — | JP | disclosed |
| EP-0672648-B1 | Threo (2R,3S)-3-amino-2-hydroxypentanoic acid and threo (2R,3S)-3-(p-methoxy-benzyloxycarbonyl/FMOC) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU (JP) | 1998-09-23 | — | — | EP | disclosed |
| US-5541290-A | OLIGOPEPTIDE CONTAINING ALPHA-KETOAMIDE GROUP, TREATMENT OF ALZHEIMER*S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS | CORTEX PHARMACEUTICALS, INC. | 1996-07-30 | — | — | US | disclosed |
| EP-0672648-A1 | Threo-3-amino-2-hydroxypentanoic acid and threo (2R,3S), (2S,3R)-3-(p-methoxy-benzyloxycarbonyl) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1995-09-20 | — | — | EP | disclosed |
| EP-0672648-A1 | Threo-3-amino-2-hydroxypentanoic acid and threo (2R,3S), (2S,3R)-3-(p-methoxy-benzyloxycarbonyl) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1995-09-20 | — | — | EP | disclosed |
| EP-0672648-A1 | Threo-3-amino-2-hydroxypentanoic acid and threo (2R,3S), (2S,3R)-3-(p-methoxy-benzyloxycarbonyl) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1995-09-20 | — | — | EP | disclosed |
| US-5359138-A | Endopeptidase inhibitors for treatment of amnesia and autoimmune diseases | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1994-10-25 | — | — | US | disclosed |
| US-5162500-A | POSTSTATIN AND RELATED COMPOUNDS OR SALTS THEREOF | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1992-11-10 | — | — | US | disclosed |
| JP-H041162-A | OPTICALLY ACTIVE THREO-3-AMINO-2-HYDROXYPENTANOIC ACID AND PRODUCTION THEREOF | MICROBIAL CHEM RES FOUND | 1992-01-06 | — | — | JP | disclosed |
| EP-0423358-A1 | POSTOSTATIN AND RELATED COMPOUND THEREOF, OR THEIR SALTS | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1991-04-24 | — | — | EP | disclosed |