Dexbudesonide

Dexbudesonide

SCHEMBL865033

CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Dexbudesonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 known ✓ P04150 13/20 1.00
PGR P06401 7/20 1.00
CYP3A4 P08684 3/20 1.00
HIF1A Q16665 2/20 1.00
CYP2C9 P11712 2/20 1.00
ABCC3 O15438 1/20 1.00
ABCC4 O15439 1/20 1.00
ABCB11 O95342 1/20 1.00
IL5 P05113 1/20 1.00
NR3C2 P08235 1/20 1.00
AR P10275 1/20 1.00
CHRM1 P11229 1/20 1.00
MMP9 P14780 1/20 1.00
NFKB1 P19838 1/20 1.00
THPO P40225 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
HSD17B10 Q99714 1/20 1.00
LMNA P02545 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Budesonide SCHEMBL16139563 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL17168987 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL9763339 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL12440030 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL19635 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL10020756 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL17151422 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL17971368 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL13918824 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9
Budesonide SCHEMBL21570019 1.00 NR3C1 (1.00) NR3C1PGRCYP3A4HIF1ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240050317-A1 SYSTEM AND METHOD FOR MAKING PERSONALIZED INDIVIDUAL UNIT DOSES CONTAINING PHARMACEUTICAL ACTIVES AQUESTIVE THERAPEUTICS, INC. (US) 2024-02-15 US disclosed
EP-3566841-B1 MANUFACTURING OF SMALL FILM STRIPS AQUESTIVE THERAPEUTICS INC (US) 2024-02-07 EP disclosed
EP-4304554-A1 DOSAGE FORMS HAVING EQUIVALENT BIOCOMPARABLE PROFILES Aquestive Therapeutics, Inc. (US) 2024-01-17 EP disclosed
US-20230414452-A1 SYSTEM AND METHOD FOR MAKING PERSONALIZED INDIVIDUAL UNIT DOSES CONTAINING PHARMACEUTICAL ACTIVES AQUESTIVE THERAPEUTICS, INC. (US) 2023-12-28 US disclosed
EP-4277611-A1 PRODRUG COMPOSITIONS AND METHODS OF TREATMENT Aquestive Therapeutics, Inc. (US) 2023-11-22 EP disclosed
US-11806311-B2 System and method for making personalized individual unit doses containing pharmaceutical actives AQUESTIVE THERAPEUTICS, INC. (US) 2023-11-07 US disclosed
US-20230149304-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2023-05-18 US disclosed
US-20230145752-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2023-05-11 US disclosed
WO-2023076281-A1 ORAL AND NASAL COMPOSITIONS AND METHODS OF TREATMENT AQUESTIVE THERAPEUTICS, INC. (US) 2023-05-04 WO disclosed
US-20230131450-A1 ORAL AND NASAL COMPOSITIONS AND METHODS OF TREATMENT AQUESTIVE THERAPEUTICS, INC. (US) 2023-04-27 US disclosed
WO-2004030659-A1 SUSTAINED RELEASE POROUS MICROPARTICLES FOR INHALATION ACUSPHERE, INC. (US) 2004-04-15 WO disclosed
WO-2004023984-A2 NOVEL COMPOSITION AND METHOD FOR TREATMENT OF UPPER RESPIRATORY CONDITIONS SMITH C STEVEN (US) 2004-03-25 WO disclosed
EP-1033991-B1 MOMETASONE FUROATE SUSPENSIONS FOR NEBULIZATION SCHERING CORP (US) 2002-04-17 EP disclosed
US-6250300-B1 System for dispensing pharmaceutically active compounds AB ASTRA (SE) 2001-06-26 US disclosed
US-6187765-B1 CONTAINING NONIONIC SURFACTANT, SODIUM OR POTASSIUM CHLORIDE, WATER AND, OPTIONALLY, A PH BUFFER SCHERING CORPORATION 2001-02-13 US disclosed
EP-1033991-A1 MOMETASONE FUROATE SUSPENSIONS FOR NEBULIZATION SCHERING CORPORATION (US) 2000-09-13 EP disclosed
US-5934273-A System for dispensing pharmaceutically active compounds AB ASTRA (SE) 1999-08-10 US disclosed
WO-1999018971-A1 MOMETASONE FUROATE SUSPENSIONS FOR NEBULIZATION SCHERING CORPORATION (US) 1999-04-22 WO disclosed
US-5642728-A System for dispensing pharmaceutically active compounds AB ASTRA (SE) 1997-07-01 US disclosed
US-5049389-A Non-phospholipd lipid, delivery by inhalation LIPOSOME TECHNOLOGY, INC. (US) 1991-09-17 US disclosed