Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808736 | 0.85 | CYP1A2 (0.65) | CYP1A2KDM4EL3MBTL1ALDH1A1GAA | |
| SCHEMBL8647344 | 0.84 | KMT2A (0.58) | CYP1A2KDM4EL3MBTL1ALDH1A1GAA | |
| SCHEMBL8651102 | 0.84 | SMN1; SMN2 (0.67) | CYP1A2KDM4EALDH1A1GAAHTT | |
| SCHEMBL2813628 | 0.82 | CYP1A2 (0.65) | CYP1A2KDM4EL3MBTL1ALDH1A1GAA | |
| SCHEMBL2808061 | 0.81 | MEN1 (0.63) | CYP1A2KDM4EALDH1A1GAAHTT | |
| SCHEMBL2811844 | 0.81 | MEN1 (0.63) | FAAHCYP1A2KDM4EALDH1A1GAA | |
| SCHEMBL13132593 | 0.81 | CYP1A2 (0.46) | CYP1A2KDM4EL3MBTL1ALDH1A1GAA | |
| SCHEMBL8651246 | 0.80 | KDM4E (0.50) | FAAHCYP1A2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL28395058 | 0.80 | ALDH1A1 (0.70) | FAAHCYP1A2KDM4EALDH1A1GAA | |
| SCHEMBL8647443 | 0.80 | KMT2A (0.62) | KDM4EALDH1A1GAASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807688-A | ANTIBODY DIRECTED ANZYME PRODRUG THERAPY | ZENECA LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |
| EP-0745673-A2 | Catalytic antibody regulated prodrug therapy | ZENECA LIMITED (GB) | 1996-12-04 | — | — | EP | disclosed |