Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | RARA | P10276 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 2/20 | 0.47 |
| ▸ | RARG | P13631 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899988 | 1.00 | TTR (0.60) | TTRTSHRSRD5A2RARARARB | |
| SCHEMBL8650815 | 1.00 | TTR (0.60) | TTRTSHRSRD5A2RARARARB | |
| SCHEMBL5692715 | 0.89 | TTR (0.72) | TTRRARARARBRARGBACE1 | |
| SCHEMBL5692713 | 0.89 | TTR (0.72) | TTRRARARARBRARGBACE1 | |
| SCHEMBL5750731 | 0.83 | CYP1A1 (0.54) | TTRALDH1A1FBP1KMT2A | |
| SCHEMBL5253903 | 0.83 | CYP1A1 (0.54) | TTRALDH1A1FBP1KMT2A | |
| SCHEMBL5253901 | 0.83 | CYP1A1 (0.54) | TTRALDH1A1FBP1KMT2A | |
| SCHEMBL5692936 | 0.81 | TTR (0.51) | TTRRARARARBRARGKMT2A | |
| SCHEMBL5692938 | 0.81 | TTR (0.51) | TTRRARARARBRARGKMT2A | |
| SCHEMBL16687965 | 0.81 | ALDH1A1 (0.56) | TTRTSHRSRD5A2RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767268-A | TREATMENT OF DISORDERS CHARACTERIZED BY EXCESSIVE OR DESTRUCTIVE PROLIFERATION OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-16 | — | — | US | claimed |
| US-5767268-A | TREATMENT OF DISORDERS CHARACTERIZED BY EXCESSIVE OR DESTRUCTIVE PROLIFERATION OF SMOOTH MUSCLE CELLS | HOFFMANN-LA ROCHE INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0663391-B1 | Sulphuric acid esters of sugar alcohols for the treatment of arteriosclerotic changes in the vascular walls | HOFFMANN LA ROCHE (CH) | 1997-04-09 | — | — | EP | disclosed |
| EP-0741139-A1 | Sulphuric acid esters of amino sugars | F. HOFFMANN-LA ROCHE AG (CH) | 1996-11-06 | — | — | EP | disclosed |
| US-5521160-A | COMPOUNDS FOR TREATMENT OF ATHERIOSCLEROSIS IN BLOOD VESSELS AND PREVENTION OF RESTENOSIS AFTER ANGIOPLASTY | HOFFMANN-LA ROCHE INC. (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0663391-A1 | Sulphuric acid esters of sugar alcohols for the treatment of arteriosclerotic changes in the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1995-07-19 | — | — | EP | disclosed |