Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643112 | 0.96 | KMT2A (0.37) | KMT2ARAB9ASMN1; SMN2NPC1HDAC1 | |
| SCHEMBL8643120 | 0.84 | MAPT (0.51) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8643116 | 0.84 | KMT2A (0.37) | KMT2ARAB9ASMN1; SMN2NPC1HDAC1 | |
| SCHEMBL8646247 | 0.82 | MAPT (0.46) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8644175 | 0.81 | KMT2A (0.43) | KMT2ARAB9ASMN1; SMN2NPC1HDAC1 | |
| SCHEMBL8644173 | 0.81 | KMT2A (0.43) | KMT2ARAB9ASMN1; SMN2NPC1HDAC1 | |
| SCHEMBL8646364 | 0.76 | MAPT (0.44) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8649037 | 0.75 | ATM (0.42) | KMT2ARAB9ASMN1; SMN2NPC1HDAC1 | |
| SCHEMBL19341349 | 0.74 | CA1 (0.43) | KMT2ARAB9ASMN1; SMN2NPC1HDAC1 | |
| SCHEMBL8648196 | 0.72 | HDAC1 (0.46) | KMT2ARAB9ANPC1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861831-A1 | HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |