SCHEMBL8652195

SCHEMBL8652195

Clc1ccc(-c2ccc(Cl)c(Cl)c2)cc1Cl.Clc1ccccc1-c1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.71
AHR P35869 5/20 0.58
HSD11B1 P28845 1/20 0.51
CYP1B1 Q16678 1/20 0.50
ESR2 Q92731 1/20 0.48
MAOB P27338 2/20 0.47
PTGER1 P34995 1/20 0.46
PTGER3 P43115 1/20 0.46
PTGER2 P43116 1/20 0.46
ADORA1 P30542 1/20 0.45
CSNK2A1 P68400 2/20 0.43
LMNA P02545 1/20 0.42
TSHR P16473 1/20 0.42
EIF4E P06730 1/20 0.42
USP7 Q93009 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29617534 0.89 AHR (0.60) CYP2A6AHRHSD11B1CYP1B1MAOB
SCHEMBL3111742 0.89 AHR (0.60) CYP2A6AHRHSD11B1CYP1B1MAOB
SCHEMBL9636468 0.87 CYP2A6 (0.84) CYP2A6HSD11B1ESR2MAOBCSNK2A1
SCHEMBL1443418 0.84 AHR (0.74) CYP2A6AHRCYP1B1ESR2PTGER1
SCHEMBL6436152 0.84 CYP2A6 (0.90) CYP2A6HSD11B1ESR2MAOBCSNK2A1
SCHEMBL29493845 0.84 AHR (0.74) CYP2A6AHRCYP1B1ESR2PTGER1
SCHEMBL23628571 0.84 CYP2A6 (1.00) CYP2A6HSD11B1MAOBCSNK2A1LMNA
SCHEMBL170230 0.84 CYP2A6 (1.00) CYP2A6HSD11B1MAOBCSNK2A1LMNA
SCHEMBL29355088 0.84 CYP2A6 (1.00) CYP2A6HSD11B1MAOBCSNK2A1LMNA
Benzene SCHEMBL28342327 0.84 CYP2A6 (1.00) CYP2A6HSD11B1MAOBCSNK2A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5877389-A Process for the oxidative decomposition of organic compounds present in aqueous effluents ELF AQUITAINE (FR) 1999-03-02 US disclosed