Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 14/20 | 0.77 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.73 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.47 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.45 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.45 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650874 | 0.89 | MTNR1B (0.77) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL5871334 | 0.87 | MTNR1B (1.00) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL8661290 | 0.85 | MTNR1B (0.79) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL8652636 | 0.85 | MTNR1B (0.77) | MTNR1BMTNR1AKMT2ANQO2 | |
| SCHEMBL8652117 | 0.85 | MTNR1B (1.00) | MTNR1BMTNR1A | |
| SCHEMBL8648792 | 0.84 | MTNR1B (0.77) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL8650941 | 0.84 | MTNR1B (1.00) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL8650947 | 0.84 | MTNR1B (1.00) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL8650990 | 0.84 | MTNR1B (0.77) | MTNR1BMTNR1A | |
| SCHEMBL8652933 | 0.84 | MTNR1B (0.78) | MTNR1BMTNR1ANQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745597-A2 | Novel melatonergic indanyl piperazines or homopiperazines | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-04 | — | — | EP | claimed |
| US-5780470-A | TREATING SLEEP DISORDERS AND DEPRESSION | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-07-14 | — | — | US | disclosed |
| EP-0745597-A2 | Novel melatonergic indanyl piperazines or homopiperazines | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-04 | — | — | EP | disclosed |