Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL29276824 | 0.97 | ALDH1A1 (0.53) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL27592422 | 0.97 | ALDH1A1 (0.53) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL29165682 | 0.90 | ALDH1A1 (0.69) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL6138056 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL27668291 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL4161303 | 0.86 | ALDH1A1 (0.47) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL27603063 | 0.84 | ALDH1A1 (0.60) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL4418408 | 0.84 | ALDH1A1 (0.60) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL396019 | 0.79 | ALDH1A1 (0.75) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 | |
| Biphenyl SCHEMBL28611575 | 0.79 | ALDH1A1 (0.75) | ALDH1A1TAAR1MAPK1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-B1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1998-10-07 | — | — | EP | disclosed |
| US-5663180-A | ANTIARTHRITIC, ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| US-5420287-A | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1995-05-30 | — | — | US | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |
| US-5344991-A | Sulfonyl or sulfamyl derivatives for treatment of arthritis and pain | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | disclosed |