SCHEMBL8655332

SCHEMBL8655332

Cc1csc2ccc(O)c(C=O)c12

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 10/20 0.46
CYP3A4 P08684 1/20 0.33
MAPT P10636 1/20 0.33
CYP2A6 P11509 4/20 0.33
HTR2B P41595 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3483555 0.73 CYP2A6 (0.43) CYP3A4MAPTCYP2A6HTR2B
SCHEMBL4426300 0.72 CYP2A6 (0.46) CYP2A6
SCHEMBL7717189 0.69 ERN1 (0.49) ERN1CYP3A4MAPT
SCHEMBL31351301 0.69 ERN1 (0.49) ERN1CYP3A4MAPT
SCHEMBL28481670 0.68 TRPA1 (0.41) CYP3A4MAPTCYP2A6
SCHEMBL16693080 0.68 CYP2A6 (0.47) ERN1MAPTCYP2A6
SCHEMBL841552 0.67 CYP3A4 (0.48) ERN1CYP3A4MAPT
SCHEMBL3312483 0.67 ERN1 (0.47) ERN1CYP3A4MAPT
SCHEMBL29111409 0.67 ERN1 (0.56) ERN1
SCHEMBL12767716 0.67 ERN1 (0.51) ERN1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5770544-A TRIAZINES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-06-23 US disclosed
US-5616537-A Condensed heterocyclic derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1997-04-01 US disclosed
EP-0606489-A1 CONDENSED HETEROCYCLIC DERIVATIVE AND WEEDKILLER KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1994-07-20 EP disclosed