Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653060 | 0.93 | PTGS2 (0.52) | PTGS2PTGS1GPR119KIF11 | |
| SCHEMBL8658464 | 0.91 | PTGS2 (0.52) | PTGS2PTGS1GPR119KDM1AMAOB | |
| SCHEMBL8651282 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1GPR119KDM1AMAOB | |
| SCHEMBL8656367 | 0.89 | PTGS2 (0.51) | PTGS2PTGS1KDM1AMAOBKIF11 | |
| SCHEMBL8655765 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1GPR119STAT3 | |
| SCHEMBL8656488 | 0.86 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8653567 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1GPR119STAT3 | |
| SCHEMBL8654229 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1GPR119KDM1AMAOB | |
| SCHEMBL8656357 | 0.86 | PTGS2 (0.68) | PTGS2PTGS1KIF11 | |
| SCHEMBL8655566 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-B1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1998-10-07 | — | — | EP | disclosed |
| US-5663180-A | ANTIARTHRITIC, ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5420287-A | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1995-05-30 | — | — | US | disclosed |
| US-5344991-A | Sulfonyl or sulfamyl derivatives for treatment of arthritis and pain | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | disclosed |