Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8655711 | 1.00 | HTT (0.51) | HTTALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL11057185 | 0.85 | HTT (0.53) | HTTALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL10725924 | 0.85 | HTT (0.53) | HTTALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL10725915 | 0.85 | HTT (0.53) | HTTALDH1A1GAAPOLBL3MBTL1 | |
| SCHEMBL30278688 | 0.84 | ALDH1A1 (0.46) | HTTALDH1A1GAAPOLBHSD11B1 | |
| SCHEMBL21895832 | 0.84 | ALDH1A1 (0.46) | HTTALDH1A1GAAPOLBHSD11B1 | |
| SCHEMBL21895831 | 0.84 | ALDH1A1 (0.46) | HTTALDH1A1GAAPOLBHSD11B1 | |
| SCHEMBL7349201 | 0.83 | ALDH1A1 (0.64) | ALDH1A1GAAPOLBL3MBTL1MAPK1 | |
| SCHEMBL7349189 | 0.83 | ALDH1A1 (0.64) | ALDH1A1GAAPOLBL3MBTL1MAPK1 | |
| SCHEMBL10166837 | 0.81 | ALDH1A1 (0.42) | HTTALDH1A1GAAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723602-A | ANGIOTENSIN CONVERTING ENZYME AND ENDOPEPTIDASE INHIBITORS, CARDIOVASCULAR DISORDERS | E. R. SQUIBB & SONS, INC. (US) | 1998-03-03 | — | — | US | disclosed |
| US-4661479-A | ENZYME INHIBITORS | MERCK AND CO., INC. (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0061187-B1 | BICYCLIC LACTAMS AS ANTIHYPERTENSIVES | MERCK & CO. INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4415496-A | HYPOTENSIVE AGENTS; 5-OXOTHIAZOLO/3,2-A/AZEPINE DERIVATIVES FROM A PHTHALIMIDE | MERCK & CO., INC. (US) | 1983-11-15 | — | — | US | disclosed |
| EP-0061187-A1 | Bicyclic lactams as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | disclosed |