SCHEMBL8655836

SCHEMBL8655836

CN(C)CP(c1ccccc1)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
TSHR P16473 2/20 0.42
HTR2A P28223 3/20 0.39
HRH1 P35367 3/20 0.39
TAAR1 Q96RJ0 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
CYP3A4 P08684 2/20 0.39
AOC3 Q16853 1/20 0.34
SIGMAR1 Q99720 1/20 0.34
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
USP2 O75604 1/20 0.33
LMNA P02545 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
PYCR1 P32322 1/20 0.33
MAPT P10636 1/20 0.33
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7034470 0.85 CYP3A4 (0.39) ALDH1A1TSHRHTR2AHRH1TAAR1
SCHEMBL7036393 0.81 CYP3A4 (0.36) ALDH1A1TSHRHTR2AHRH1TAAR1
SCHEMBL9190955 0.79 CYP3A4 (0.43) TDP1CYP3A4ESR1ESR2
SCHEMBL8780860 0.79 TDP1 (0.43) ALDH1A1TSHRTDP1CYP3A4ESR1
SCHEMBL5003760 0.76 KCNH2 (0.41) ALDH1A1TSHRHTR2AHRH1TDP1
SCHEMBL3164447 0.76 TAAR1 (0.46) ALDH1A1TSHRHTR2AHRH1TAAR1
SCHEMBL8652282 0.76 KCNH2 (0.41) ALDH1A1TSHRHTR2AHRH1TDP1
SCHEMBL20027358 0.76 LMNA (0.53) ALDH1A1TSHRHTR2ACYP3A4AOC3
SCHEMBL9187620 0.75 TDP1 (0.39) ALDH1A1TSHRTAAR1TDP1CYP3A4
SCHEMBL6242982 0.75 CYP3A4 (0.35) ALDH1A1TAAR1TDP1CYP3A4ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729448-B1 PROCESS FOR THE PREPARATION OF ETHYLENICALLY UNSATURATED COMPOUNDS SHELL INT RESEARCH (NL) 1998-10-14 EP disclosed
EP-0729448-A1 PROCESS FOR THE PREPARATION OF ETHYLENICALLY UNSATURATED COMPOUNDS SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1996-09-04 EP disclosed
WO-1995014001-A1 PROCESS FOR THE PREPARATION OF ETHYLENICALLY UNSATURATED COMPOUNDS SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1995-05-26 WO disclosed