Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21028290 | 0.81 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL235219 | 0.73 | NOTUM (0.59) | HTR2AHTR2CNOTUMSIGMAR1 | |
| SCHEMBL19930594 | 0.73 | HTR2A (0.53) | HTR2AHTR2CNOTUMSIGMAR1 | |
| SCHEMBL20080086 | 0.70 | HTR2A (0.50) | HTR2AHTR2CNOTUMSIGMAR1 | |
| SCHEMBL8447696 | 0.70 | HTR2A (0.43) | HTR2AHTR2CNOTUMSIGMAR1DAO | |
| Acetic Acid SCHEMBL13279290 | 0.68 | HTR2A (0.55) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL13279281 | 0.67 | HTR2A (0.40) | HTR2AHTR2CNOTUMSIGMAR1DAO | |
| SCHEMBL8449826 | 0.66 | MAPT (0.42) | HTR2AHTR2CNOTUMSIGMAR1DAO | |
| SCHEMBL10735669 | 0.66 | HTR2A (0.56) | HTR2AHTR2CNOTUMSIGMAR1 | |
| SCHEMBL30684257 | 0.66 | HTR2A (0.56) | HTR2AHTR2CNOTUMSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721245-A | ANTIINFLAMMATORY AGENTS, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0384349-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1994-04-27 | — | — | EP | disclosed |
| EP-0384349-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |